Welcome to the Abou Alaiwa lab!
Our Research
The focus of our lab research lies at the junction of the traditional disciplines of Biomedical Engineering, Medicine, and Physics. Research leverages experience in image analysis, respiratory physiology, and animal models help to advance understanding of many problems in natural sciences, especially those related to human health. In this context, the lab developed a unique perspective and novel tools to drive this research in two significant problem areas: (1) Designing novel biomedical imaging tools and techniques to study mucociliary transport in the airways. (2) Applying these techniques to understand the role mucociliary transport defects in the pathogenesis of many airway diseases such as cystic fibrosis (CF), primary ciliary dyskinesia (PCD), asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and idiopathic pulmonary fibrosis (IPF).
Mahmoud Abou Alaiwa, MD
Pulmonary, Critical Care, & Occupational Medicine
6336 PBDB
mahmoud-aboualaiwa@uiowa.edu
Lab Members
Publications
Berkebile, A. R., Bartlett, J. A., Abou Alaiwa, M., Varga, S. M., Power, U. F. & McCray, Jr, P. B. (2020). Airway Surface Liquid Has Innate Antiviral Activity That Is Reduced in Cystic Fibrosis. American journal of respiratory cell and molecular biology 62 (1) 104-111. PMCID: PMC6938132.
Hamilton, B. A., Li, X., Pezzulo, A. A., Abou Alaiwa, M. H. & Zabner, J. (2019). Polarized AAVR expression determines infectivity by AAV gene therapy vectors. Gene therapy 26 (6) 240-249. PMCID: PMC6588428.
Fischer, A. J., Pino-Argumedo, M. I., Hilkin, B. M., Shanrock, C. R., Gansemer, N. D., Chaly, A. L., Zarei, K., Allen, P. D., Ostedgaard, L. S., Hoffman, E. A., Stoltz, D. A., Welsh, M. J. & Abou Alaiwa, M. H. (2019). Mucus strands from submucosal glands initiate mucociliary transport of large particles. JCI insight 4 (1). PMCID: PMC6485365.
Xie, Y., Ostedgaard, L., Abou Alaiwa, M. H., Lu, L., Fischer, A. J. & Stoltz, D. A. (2018). Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways. Annals of the American Thoracic Society 15 (Suppl 3) S171-S176. PMCID: PMC6322029.
Abou Alaiwa, M. H., Launspach, J. L., Grogan, B., Carter, S., Zabner, J., Stoltz, D. A., Singh, P. K., McKone, E. F. & Welsh, M. J. (2018). Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis. JCI insight 3 (15). PMCID: PMC6129116.
All Publications
See Dr. Abou Alaiwa's complete list of publications on PubMed.
Office Location:
6338 PBDB
Iowa City, IA 52246
Ph: 319-384-1107